“Yiging” or the “Book of Change” is the oldest script of humanity containig a code of yin and yang creating a mathematical system of 4 doublets 8 trigrams resulting in 64 hexagrams. This coding-system can be adapted to various systems of knowlege among them also the genetic code. Therefore the idea came up to use hexagrams to test for diseases. Practitioners perform this by applying the most sensitive kinesiologic test, the pulse-reflex described by Nogier. 60 of the 64 hexagrams can represent a disease or a group of diseases. The most frequent diseases are revealed by a positive hexagram diagnosis.