The prevalence of deep vein thrombosis during TB disease is estimated at 1.5 to 3.4%. This association can worsen the prognosis of the patient hence the need for diagnosis and early management. Our goals are to report two cases of association of pulmonary tuberculosis and deep vein thrombosis and to determine the mechanism of this association.
The first case was a 40-year-old woman clinically presenting with chronic cough, fever and general impairment. Sputum examination was negative for tuberculosis and PCR GeneXpert® test was positive. In addition she had edema of the right lower limb suggestive of deep vein thrombosis confirmed by venous doppler ultrasonography. A treatment combining antituberculosis and fluindione was started with a good evolution after 3 months of anticoagulant treatment.
The second case was a 55-year-old man with chronic fever and hemoptysis with general impairment. The diagnosis of pulmonary tuberculosis was made using the GeneXpert® test to the bronchoalveolar lavage. A painful left malleolar edema appeared on the 6th day of TB treatment in favor of venous thrombosis of the lower limb confirmed by venous Doppler ultrasonography. The evolution was favorable under 6 months of antituberculous treatment and Fluindione for 3 months.
Conclusion : Deep vein thrombosis and tuberculosis is an association not to neglect.