MICROSATELLITE INSTABILITY (MSI) AND BRAF MUTATION IN COLORECTAL CARCINOMAS
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Tags : braf, colorectalcarcinoma, microsatelliteinstability, mismatch-repair
Category : Original articles
Authors : Daniel Lerda, Edith Illescas, Jorge Labrador
Background: approximately 15% of colorectal carcinomas (CRC) display high
microsatellite instability (MSI-H).
These originate when the DNA mismatchrepair system, known as the MMR system, is dysfunctional,
which results in the accumulation of mutations caused by DNA polymerase, like point mutations, deletions
and in[...]